General Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/LTB4/G15 Stable Cell L
The dihydroxy-leukotriene leukotriene B4 (LTB4) is a member of the G protein-coupled receptor (GPCR) family in a subfamily of GPCRs that includes receptors for chemokines and other chemotactic factors Recently a second lower affinity receptor for LTB4 (BLT2) has also been cloned with broader ligand specificity for various eicosanoids LTB4 stimulates neutrophil chemotaxis and secretion but may also affect immunomodulation contraction of certain smooth muscles via an indirect mechanism and activation of the nuclear transcription factor PPAR (peroxisome proliferation activated receptor alpha) Chemotaxis the principal effects of LTB4 and related dihydroxy-acids on leukocytes occurs via activation of BLT1 receptors
Genscript Corporation CHO-K1/CD155 Stable Cell Line
CD155 commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5) is a type I transmembrane single-span glycoprotein and belongs to the nectins and nectin-like (Necl) subfamily CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV) an etiologic agent of the central nervous system disease poliomyelitis The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells CD155 may assist in an efficient humoral immune response generated within the intestinal immune system It s been shown that CD155 can be recognized and bind by DNAM-1 and CD96 which promotes the adhension migration and NK-cell killing Thus inducing cell-mediated tumor-specific immunity
Genscript Corporation CHO-K1/CD32C 13Gln Stable Cell
Recombinant CHO-K1 cells stably overexpress Homo sapiens cell-type natural killer cells Fc gamma receptor IIc1 (Fc RIIc / CD32C) on the cell surface The surface expression of Fc RIIc is validated by FACS analysis This stable cell line is recommended for evaluating the binding affinity between Fc RIIc and Fc region of antibodies Fc fusion proteins or antibody-based biologics
Genscript Corporation CHO-K1/OPRD1/G15 Stable Cell
Recombinant CHO-K1 cells stably overexpress human opioid receptor delta 1 (OPRD1) on the surface and contain high levels of G protein G i to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/cyno CTLA4 Stable Cell
CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) also known as CD152 (cluster of differentiation 152) is a protein receptor that functioning as an immune checkpoint downregulates immune responses CTLA4 is constitutively expressed in Tregs but only upregulated in conventional T cells after activation It acts as an
Genscript Corporation CHO-K1/CD64 Stable Cell Line
Recombinant CHO-K1 cells stably overexpress high affinity human Fc fragment of IgG receptor Ia (Fc RI CD64) on the cell surface containing one alpha chain and two gamma chains The surface expression of CD64 is validated by FACS analysis This stable cell line product is designed for measuring the binding affinity and stability of the Fc region of antibodies Fc fusion proteins or antibody based biologics that bind with CD64 during biologics research and development
Genscript Corporation CHO-K1/CMKLR1/G15 Stable Cell
The orphan receptor ChemR23 (also referred to as CMKLR1 or DEZ) is a G-protein coupled receptor (GPCR) with homology to neuropeptide and chemoattractant receptors ChemR23 is also a G i-linked receptor expressed primarily by monocytes M s and plasmacytoid dendritic cells CMKLR1 has been shown to be expressed by DC generated in vitro from monocytes to mediate their migration to the proteolytically regulated chemoattractant chemerin and CMKLR1 may be a key mediator of pDC recruitment from the blood into tissue sites enriched in active chemerin
Genscript Corporation CHO-K1/D2s/G15 Stable Cell Li
The short form of D2 (D2S) and the long form (D2L) are two isoforms that contribute differentially to dopamine signaling in both prefrontal cortex and striatum The D2 dopamine receptor short form (D2s) has been shown to stimulate phospholipase D (PLD) activity independent of the activation of phospholipase C (PLC) activity in GH4 derived cells stably transfected with the D2s receptor Agonist activation of D2s has been shown to mediate the inhibition of growth in the same cell line
Genscript Corporation CHO-K1/D5/G15 Stable Cell Lin
Dopamine is the predominant catecholamine neurotransmitter found in mammalian brain where it controls a variety of functions including locomotor activity cognition emotion positive reinforcement food intake and endocrine regulation It also plays multiple roles in the periphery as a modulator of cardiovascular function catecholamine release hormone secretion vascular tone renal function and gastrointestinal motility The dopamine receptor family consists of five members which are classified into two groups D1-like (D1 and D5) and D2-like (D2 D3 and D4) D5 receptor has a 10-fold higher affinity for dopamine than the D1 receptor
Genscript Corporation CHO-K1/CD38 Stable Cell Line
Recombinant CHO-K1 cells stably overexpress human CD38 on the surface The surface expression of CD38 is validated by FACS analysis
Genscript Corporation CHO-K1/MTLR/G15 Stable Cell L
The motilin receptor (MTLR) represents a clinically useful pharmacological target as agonists binding to the MTLR have gastroprokinetic properties Motilin is a 22 amino acid peptide that potently stimulates gastrointestinal contractility The biological effects of motilin are mediated by a G sub q /sub -coupled seven transmembrane protein currently termed motilin receptor (MR) that shares significant sequence similarity with the ghrelin receptor The motilin receptor is also activated by the antibiotic erythromycin this interaction appears to mediate some of the gastrointestinal side effects of erythromycin Although motilides (non-antibiotic derivatives of erythromycin) such as ABT-229 have been investigated for treatment of diabetic gastroporesis the effectiveness has been limited by tachyphylaxis (decreased response to ligand) resulting from receptor downregulation Agonists of the motilin receptor with reduced densensitization activity remain a potential treatment for dis
Genscript Corporation CHO-K1/OX40 Stable Cell Line
OX40 (CD134) is a member of the TNFR/TNF superfamily Costimulatory signals from OX40 to a conventional T cell promotes division and survival augmenting the clonal expansion of effector and memory populations as they are being generated to antigens OX40 additionally suppresses the differentiation and activity of Treg further amplifying this process